Endocrine Abstracts

According to population registries prevalence of chronic kidney disease (CKD) in the world is about 10%. Global trends show growth of CKD due to diabetic nephropathy, chronic tubulointerstitial nephritis, secondary nephropathies. Kidney transplantation is a ‘golden standard’ in CKD treatment. Is it performed about 100 times per year in The republican research and practice center for organ and tissue transplantation. The aim of the study was to evaluate menstrual func...

Introduction: Nowadays polycystic ovarian syndrome (PCOS) appears to be one of the most common endocrine disorders that involves from 5 to 10% of women of reproductive age, reaching 75% in the structure of endocrine infertility. Furthermore the distribution of adipose tissue in android region correlates with the prognosis of diabetes, metabolic syndrome and cardiovascular diseases development.Aim of the study was to determine the type of obesity and to d...

Enteroendocrine cells (EECs) are a hormone-/neurotransmitter-producing population with well-defined physiological roles. Knowledge regarding their differentiation program in the human gut, however, is scarce. Deciphering endocrine specification could identify targets which allow the manipulation of specific EEC populations and form the basis for new treatments for metabolic, inflammatory and cognitive disorders. Isoxazole-9 (ISX-9) is a small molecule, previously used in proto...

Oestrogens impact colorectal cancer (CRC) development and proliferation. Biologically active oestrogens, oestrone (E1) and oestradiol (E2), are metabolised through hydrolysis of their sulfated forms (oestrone sulfate (E1S) and oestradiol sulfate) by steroid sulfatase (STS). We have shown that increased STS activity drives CRC proliferation via oestrogen hydrolysis. We have also identified that CRC expresses the necessary organic anion transport...

The intestinal epithelium (IE) is populated by different cell types each with a unique set of functions. Each cell type is derived from a common progenitor, the stem cell. The hierarchy of epithelial cell fate is transcriptionally regulated for example, Notch signalling defines secretory versus absorptive destiny. Peptide hormone producing enteroendocrine (EE) cells are scattered throughout the epithelium where they integrate complex nutrient signals and respond by promoting m...

Chronic kidney disease (CKD) is a global burden, with prevalence of 11–13%. CKD usually remains asymptomatic until later stages, but is strongly associated with increased risks of cardiovascular morbidity, premature mortality and decreased quality of life. Kidney transplantation (KT) is a treatment of choice for end stage CKD. KT was performed 350 times from dead donor and 6 times from living donor in the GU ‘Minsk Scientific-Practical Center of Surgery, Transplant...

Introduction: Vitamin D is involved not only in the regulation of calcium–phosphorus metabolism; it also plays an important role in maintaining the immune system, muscle strength and neuromuscular conduction. Lack of vitamin D is assumed as one of the mechanisms of autoimmune and infectious diseases. Chronic fatigue syndrome (CFS) – is a syndrome manifesting with a severe chronic physical, mental weakness, psychological disturbances such as anxiety and depression, th...

Introduction: Leydig cell hypoplasia (LCH) is a rare autosomal recessive condition that interferes with normal development of male external genitalia in 46,XY individuals. It is mediated by mutations in the luteinizing hormone receptor gene (LHCGR), most frequently located in the coding sequence, resulting in impairment of either LH/CG binding or signal transduction.Case report: We report a 32-year-old female which presented with primary amenorrhea, fema...

Introduction: Lactation is a period of particular importance regarding the management of glycemia in women with Diabetes Mellitus type 1 (DM1), the aim being to prevent hypoglycemia during breastfeeding. The purpose of this study was to investigate the variation of insulin requirements during lactation in comparison with pre-pregnancy levels in women with DM1 and to find potential correlation factors.Materials-methods: We conducted a retrospective case f...

Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes as well as its possible relation to glycemic control and to diabetic complications.Patients and methods: A total of 990 patients (60.7% men) with T1DM or T2DM, consecutively followed in the Outpatient Diabetes Clinic, participated in the study. In every patient anthropometric and biochemical measuremen...